The purpose of this blog has many uses. It allows me to create content exploring genome biology in more depth than what can be achieved in a mere 140 characters. But more ambitiously, I will be embarking on a journey of self-discovery, of the molecular and structural kind. I plan to acquire my own genome’s data at high-density read depth. I expect to catalog over 1,000,000 variations from my genome when compared to the norm. Of these variations, I expect about 1000 will be in the coding sequence of my genes. About 7% of these will be obviously deleterious to gene function. Yet, because we are diploids organisms with two copies of every gene, many of these “bad” genes will be backed up by a good copy. As a result, I will know what is my carrier status for bad alleles. Intriguingly, I will be uncovering which important genes (or hopefully not so important genes) have had two hits that render their phenotypic consequence as defective.